Advantages of VHHs as Therapeutics

VHHs are the smallest naturally-derived antibody fragments – molecular weight ~1/10 of traditional antibody – with antigen binding affinities comparable to those of conventional antibodies.


Features and advantages of VHHs

  • Superior biochemical and biophysical properties with high affinity and specificity, high solubility and stability, easy to handle
  • Rapid tissue penetration, fast clearance
  • A flexible modality, easy for genetic engineering as well as chemical modification to build multimers or multispecifics to achieve precise targeting or tunable half-life, or to be conjugated to desirable payloads including small or large molecules
  • Low immunogenicity
  • Easy to manufacture in microbial system with low costs